Mosegor Vita Mechanism of Action

Pharmacology: Properties: Pizotifen has an appetite-stimulating action suitable for increasing body weight in underweight anorectic patients. The compound is well tolerated, permitting treatment of anorexia both in children and adults.
Owing to its inhibitory effect on biogenic amines, pizotifen is also used for the prophylactic (interval) treatment of migraine.
The B-complex vitamins B₁, B₂, B₆ and nicotinamide prevent deficiencies of these vitamins often associated with inadequate food intake. Such a need may also arise from antibiotic or other drug therapy with vitamin utilization.
Pharmacokinetics: The absorption of pizotifen is fast (absorption half-life 0.5 - 0.8 hours) and nearly complete (80%). The substance is metabolized with a half-life of about 1 hour. The main metabolite (N-glucuronide) is eliminated with a half-life approx. 23 hours. The protein binding amounts to 91% and the distribution volume to 485 L. Less than 1 % of the administered dose is excreted unchanged in urine, whereas 55% is excreted as metabolites. In patients with kidney insufficiency dosage adjustment may therefore be necessary.